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However, its clinical potential was not acknowledged on the time, and no patent was filed. 2Effectiveness refers to the probability of advantages under average circumstances of use, and efficacy refers to this under ideal conditions of use. Although the regulation uses the term effectiveness, the approval decision is made on the basis of efficacy information. This paper will subsequently use the term efficacy in the context of pre-marketing scientific investigations, that is, to check with testing under ideal situations of use. 1This concern can be evident concerning the financial analysis of new applied sciences throughout their development. This problem would be the topic of a subsequent publication, and thus is not going to be further discussed in this volume. His research curiosity includes biomechatronics, decrease limb biomechanics, prosthetics and robotics. He is an writer of 2 Journal publications, 10 peer reviewed International Conferences and a couple of summary papers. D